Catégorie
Chlorhexidine
Numéro CAS
Chlorhexidine STD-55-56-1: IMP-A-152504-08-0: IMP-B-1308292-89-8: IMP-F-140-38-5: IMP-G-152504-09-1: IMP-H-NA: IMP-J-NA: IMP-K-1381962-77-1: IMP-L-2518301-34-1: IMP-N-152504-10-4: IMP-O-2508008-02-2: IMP-Q-NA
Autre numéro CAS
Chlorhexidine STD-56-95-1(Diacetate Salt);3697-42-5(DiHCl Salt);18472-51-0(Digluconate Salt): IMP-G-165678-61-5(DiHCl Salt): IMP-N-3084279-48-8(TFA Salt)
Formule moléculaire
Chlorhexidine STD-C22H30Cl2N10: IMP-A-C16H24ClN9: IMP-B-C16H26ClN9O: IMP-F-C7H7ClN2O: IMP-G-C14H23ClN6: IMP-H-C30H47Cl2N15: IMP-J-C28H38Cl2N10O5: IMP-K-C22H29Cl2N9O: IMP-L-C13H15ClN2O6: IMP-N-C15H25ClN8: IMP-O-C22H30Cl2N10: IMP-Q-C22H34ClN9O6
Masse moléculaire
Chlorhexidine STD-505.45: IMP-A-377.9: IMP-B-395.9: IMP-F-170.6: IMP-G-310.83: IMP-H-688.7: IMP-J-665.6: IMP-K-506.43: IMP-L-330.7: IMP-N-352.9: IMP-O-505.45: IMP-Q-556.02
Synonyme

Chlorhexidine STD-(1E)-2-[6-[[amino-[(E)-[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexyl]-1-[amino-(4-chloroanilino)methylidene]guanidine; N,N’’-Bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide; 1,1’-Hexamethylenebis[5-(p-chlorophenyl)-biguanide; Chlorhexidine; Chlorohex; Chlorohexidine; Consepsis; Dentosan;1,1’-Hexamethylenebis[5-(p-chlorophenyl)biguanide]; 1,6-Bis[5-(p-chlorophenyl)biguanidino]hexane; 1,6-Di(N-p-chlorophenylbiguanidino)hexane (USP)

Chlorhexidine EP-Impurity-A-(1E)-1-[amino-(4-chloroanilino)methylidene]-2-[6-[[amino-(cyanoamino)methylidene]amino]hexyl]guanidine; Chlorhexidine Digluconate Solution - Impurity A (EP/BP); N-(4-Chlorophenyl)-N'-[6-[[(cyanoamino)iminomethyl]amino]hexyl]imidodicarbonimidic Diamide; 1-(4-Chlorophenyl)-5-[6-(3-cyanoguanidino)hexyl]biguanide; Chlorhexidine nitrile; 1-(4-Chlorophenyl)-5-[6-[(cyanocarbamimidoyl)amino]hexyl]biguanide (USP)

Chlorhexidine EP-Impurity-B-[N'-[6-[[amino-[(E)-[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexyl]carbamimidoyl]urea; Chlorhexidine Digluconate Solution - Impurity B (EP/BP); Chlorhexidine Dihydrochloride - Impurity B (EP/BP); 14-[(4-Chlorophenyl)amino]-3,12,14-triimino-2,4,11,13-tetraazatetradecanamide;[[6-[[[(4-Chlorophenyl)carbamimidoyl]carbamimidoyl]amino]hexyl]carbamimidoyl]urea; Chlorhexidine urea; N-{[6-({[(4-Chlorophenyl)carbamimidoyl]carbamimidoyl}amino)hexyl]carbamimidoyl}urea (USP)

Chlorhexidine EP-Impurity-F-(4-chlorophenyl)urea; Chlorhexidine Digluconate Solution - Impurity F (EP/BP); Chlorhexidine Dihydrochloride - Impurity F (EP/BP); 4-Chlorophenylurea; N-(4-Chlorophenyl)urea; (p-Chlorophenyl)urea;1-(4-Chlorophenyl)urea; 3-(p-Chlorophenyl)urea; 4-Chlorophenylurea; NSC 12971; NSC 400071; p-Chlorophenyl urea; 1-(4-Chlorophenyl)urea (USP)

Chlorhexidine EP-Impurity-G-(1E)-1-[amino-(4-chloroanilino)methylidene]-2-(6-aminohexyl)guanidine; Chlorhexidine Digluconate Solution - Impurity G (EP/BP); Chlorhexidine Dihydrochloride - Impurity G (EP/BP); Chlorhexidine amine (USP); 1-(6-Aminohexyl)-5-(4-chlorophenyl)biguanide

Chlorhexidine EP-Impurity-H-1,1'-[Iminobis(carbonimidoyliminohexane-6,1-diyl)]bis[5-(4-chlorophenyl)biguanide]; N,N′-[Azanediylbis(carbonimidoylazanediylhexane-6,1-diyl)]bis[N-(4-chlorophenyl)imidodicarbonimidicdiamide] (as per EP) ; 1,5-Bis[5-(4-chlorophenyl)biguanidylhexyl]biguanide (as per USP); 1,5-Bis[5-(4-chlorophenyl)biguanidylhexyl]biguanide;Chlorhexidine Dimer (USP)

Chlorhexidine EP-Impurity-J-1-(4-Chlorophenyl)-5-[6-({4-[(4-chlorophenyl)amino]-6-[(1S,2R,3R,4R)-1,2,3,4,5-pentahydroxypentyl]-1,3,5-triazin-2-yl}amino)hexyl]biguanide; N1-[6-[[4-(4-chloroanilino)-6-[(1S,2R,3R,4R)-1,2,3,4,5-pentahydroxypentyl]-1,3,5-triazin-2-yl]amino]hexyl]-N3-(4-chlorophenyl)imidodicarbonimidic diamide

Chlorhexidine EP-Impurity-K-N-(4-Chlorophenyl)-N′-[N-[6-[[N-[N-(4-chlorophenyl)carbamimidoyl]carbamimidoyl]amino]hexyl]carbamimidoyl]urea; Chlorhexidine Digluconate Solution - Impurity K (EP/BP); Chlorhexidine Dihydrochloride - Impurity K (EP/BP); N-(4-Chlorophenyl)-14-[(4-chlorophenyl)amino]-3,12,14-triimino-2,4,11,13-tetraazatetradecanamide;1-(4-Chlorophenyl)-3-[[6-[[[(4-chlorophenyl)carbamimidoyl]carbamimidoyl]amino]hexyl]-carbamimidoyl]urea; Oxochlorhexidine; N-(4-Chlorophenyl)-N'-{[6-({[(4-chlorophenyl)carbamimidoyl]carbamimidoyl}amino)hexyl]carbamimidoyl}urea (USP)

Chlorhexidine EP-Impurity-L-(5R,6S)-2-(4-chlorophenyl)imino-5-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]-1,3-oxazinan-4-one; 4H-1,3-Oxazin-4-one, 2-[(4-chlorophenyl)amino]-5,6-dihydro-5-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]-, (5R,6S)-rel; rel-(5R,6S)-2-[(4-Chlorophenyl)amino]-5,6-dihydro-5-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]-4H-1,3-oxazin-4-one; rel-(5R,6S)-2-((4-Chlorophenyl)amino)-5-hydroxy-6-((1R,2R)-1,2,3-trihydroxypropyl)-5,6-dihydro-4H-1,3-oxazin-4-one

Chlorhexidine EP-Impurity-N-(1E)-1-[amino-(4-chloroanilino)methylidene]-2-[6-(diaminomethylideneamino)hexyl]guanidine; N-[6-[(Aminoiminomethyl)amino]hexyl]-N'-(4-chlorophenyl)-imidodicarbonimidic diamide; Chlorhexidine Digluconate Solution - Impurity N (EP/BP); Chlorhexidine Dihydrochloride - Impurity N (EP/BP); N-[6-[(Aminoiminomethyl)amino]hexyl]-N'-(4-chlorophenyl)-imidodicarbonimidic diamide; 1-[6-(Carbamimidoylamino)hexyl]-5-(4-chlorophenyl)biguanide; Chlorhexidine guanidine (USP)

Chlorhexidine EP-Impurity-O-2-[6-[[amino-[[amino-(2-chloroanilino)methylidene]amino]methylidene]amino]hexyl]-1-[amino-(4-chloroanilino)methylidene]guanidine; 1-(2-Chlorophenyl)-5-[6-[[[(4-chlorophenyl)carbamimidoyl]carbamimidoyl]amino]hexyl]biguanide; Chlorhexidine Digluconate Solution - Impurity O (EP/BP); Chlorhexidine Dihydrochloride - Impurity O (EP/BP); N1-(4-Chlorophenyl)-3,12-diimino-N14-2-chlorophenyl-2,4,11,13-Tetraazatetradecanediimidamide; o-Chlorhexidine; 1-(2-Chlorophenyl)-5-[6-({[(4-chlorophenyl)carbamimidoyl]carbamimidoyl}amino)hexyl]biguanide (USP)

Chlorhexidine EP-Impurity-Q-N1-(4-chlorophenyl)-N3-[6-[[N-[(5E,6E)-5-hydroxy-4-oxo-6-[(1R,2R)-1,2,3-trihydroxypropyl]-5,6-dihydro-4H-1,3-oxazin-2-yl]carbamimidoyl]amino]hexyl]imidodicarbonimidic diamide; N1-(4-chlorophenyl)-N3-[6-[[N-[(5Ξ,6Ξ)-5-hydroxy-4-oxo-6-[(1R,2R)-1,2,3-trihydroxypropyl]-5,6-dihydro-4H-1,3-oxazin-2-yl]carbamimidoyl]amino]hexyl]imidodicarbonimidic diamide; N1-(4-chlorophenyl)-N3-[6-[[N-[(5E,6E)-5-hydroxy-4-oxo-6-[(1R,2R)-1,2,3-trihydroxypropyl]-5,6-dihydro-4H-1,3-oxazin-2-yl]carbamimidoyl]amino]hexyl]imidodicarbonimidic diamide

slide.1
Purity:

Above - 95.0%

Technical Data:

We will provide complete documentation support for every Standard Material. All analytical reports such as ¹H NMR, ¹³C NMR, Mass, FT-IR, HPLC Purity/GC Purity/QNMR Purity, Water content by KF/ Loss on Drying/TGA (Thermo-gravimetric Analysis). Certificate of Analysis with potency report. Each Standard Material SER (Structure Elucidation Report) with NMR, Mass, IR spectral interpretation. This whole analytical document can be included in eCTD, ANDA, DMF submissions to regulatory agencies.

Chlorhexidine for System Suitability A CRS refers to the use of a Chemical Reference Substance (CRS) of chlorhexidine to verify the performance of an analytical method, typically in pharmacopoeial testing (such as HPLC). In System Suitability Test A, the chlorhexidine CRS is injected to confirm that the chromatographic system is working properly checking parameters like resolution, peak symmetry, retention time, and theoretical plates.