Catégorie
Hydrocortisone
Numéro CAS
Hydrocortisone STD - 50-23-7 : IMP - D - 53-35-0 : IMP - E - 600-99-7 : IMP - G - 14760-49-7 : IMP - H - NA : IMP - I - 103795-84-2 : IMP - N - NA
Formule moléculaire
Hydrocortisone STD - C21H30O5 : IMP - D - C21H30O6: IMP - E - C21H28O5 : IMP - G - C21H28O5 : IMP - H - C21H30O6 : IMP - I - C21H30O6 : IMP - N - C42H58O10
Masse moléculaire
Hydrocortisone STD -362.46 g/mol : IMP - D - 378.46 g/mol : IMP - E - 360.44 g/mol : IMP - G - 360.44 g/mol : IMP - H - 378.46 g/mol : IMP - I - 378.46 g/mol : IMP - N - 722.90 g/mol
Synonyme

Hydrocortisone - (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one ; (11β)-11,17,21-Trihydroxy-pregn-4-ene-3,20-dione; 11β,17,21-Trihydroxypregn-4-ene-3,20-dione; 17-Hydroxycorticosterone; 17α-Hydroxycorticosterone; NSC 10483; Cortisol, Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11b) (USP);

Hydrocortisone EP Impurity -D - (6R,8S,9S,10R,11S,13S,14S,17R)-6,11,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one ; (6beta,11beta)-6,11,17,21-Tetrahydroxypregn-4-ene-3,20-dione6beta ;17-Dihydroxycorticosterone 6beta,11beta ;6β-Hydroxy Cortisol ;

Hydrocortisone EP Impurity -E - (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-8,9,10,11,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3(2H)-one ; Pregna-4,6-diene-3,20-dione,11,17,21-trihydroxy-,(11beta)-; 

Hydrocortisone EP Impurity -G - 11beta,17-Dihydroxy-3,20-dioxopregn-4-en-21-al ; 2-((8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoacetaldehyde;

Hydrocortisone EP Impurity -H - 7alpha,11beta,17,21-Tetrahydroxypregn-4-ene-3,20-dione ; 7alpha-Hydroxyhydrocortisone ;Hydrocortisone EP Impurity -I - 11beta,14,17,21-Tetrahydroxypregn-4-ene-3,20-dione;

Hydrocortisone EP Impurity -N - 1-((10R,11S,13S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-4-((8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2,3-dihydroxybutane-1,4-dione ; 

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Purity:

Above - 95.0%

Technical Data:

We will provide complete documentation support for every Standard Material. All analytical reports such as ¹H NMR, ¹³C NMR, Mass, FT-IR, HPLC Purity/GC Purity/QNMR Purity, Water content by KF/ Loss on Drying/TGA (Thermo-gravimetric Analysis). Certificate of Analysis with potency report. Each Standard Material SER (Structure Elucidation Report) with NMR, Mass, IR spectral interpretation. This whole analytical document can be included in eCTD, ANDA, DMF submissions to regulatory agencies.

Hydrocortisone Chemical Reference Substance (CRS) is used in chromatographic and analytical methods to accurately identify and confirm hydrocortisone peaks in pharmaceutical formulations. It serves as a standard reference, ensuring proper retention time, peak resolution, and system suitability, which helps in the precise quantification and quality control of hydrocortisone in various dosage forms.