Catégorie
Lopinavir
Numéro CAS
STD - 192725-17-0 : IMP - A - 192726-05-9 : IMP - B - NA : IMP - C - NA : IMP - F - NA : IMP - G - NA : IMP - I : IMP - N - 1798014-18-2 : IMP - Q - 667904-94-1 : IMP - R - 943250-66-6: IMP - S -943250-65-5: IMP - T - 1797024-56-6 ;
Formule moléculaire
STD-C37H48N4O5:IMP-A-C27H38N4O3:IMP-B-C28H38N4O4:IMP-C-C36H52N6O5:IMP-F-C29H34N2O4:IMP-G-C30H36N2O4:IMP-I-C37H48N4O5:IMP-N-C37H48N4O5:IMP-Q-C38H44N2O5:IMP-R-C47H58N4O7:IMP-S-C47H58N4O7:IMP-T-C57H66N4O7
Masse moléculaire
STD-628.81 g/mol:IMP-A-466.63 g/mol:IMP-B -494.64 g/mol:IMP-C-648.84 g/mol:IMP-F-474.59 g/mol:IMP-G-488.62 g/mol:IMP-I-628.8 g/mol:IMP-N -628.80 g/mol:IMP-Q-608.77 g/mol:IMP-R-790.99 g/mol:IMP-S-790.99 g/mol:IMP-T-919.16 g/mol :
Synonyme

Lopinavir - (alphaS)-N-[(1S,3S,4S)-4-[[2-(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-alpha-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetamide;  (2S)-N-[(2S,4S,5S)-5-[[2-(2,6-dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide ;

Lopinavir EP Impurity - A - Lopinavir Free Amine (USP) ; (2S)-N-[(1S,3S,4S)-1-Benzyl-4-amino-3-hydroxy-5-phenylpentyl]-3-methyl-2-[2-oxotetrahydropyrimidin-1(2H)-yl]butanamide ; (2S)-N-[(2S,4S,5S)-5-amino-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide; (S)-N-[(2S,4S,5S)-5-Amino-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamide;

Lopinavir EP Impurity - B - (2S)-N-[(1S,3S,4S)-1-benzyl-4-(formylamino)-3-hydroxy5-phenylpentyl]-3-methyl-2-[2-oxotetrahydropyrimidin1(2H)-yl]butanamide;Lopinavir N-formylaminoalcohol ; (S)-N-[(2S,4S,5S)-5-Formamido-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-[2-oxotetrahydropyrimidin-1(2H)-yl]butanamide ;

Lopinavir EP Impurity - C - (2R)-N-[(1S,2S,4S)-1-benzyl-2-hydroxy-4-[[(2S)-3-methyl2-[2-oxotetrahydropyrimidin-1(2H)-yl]butanoyl]amino]-5-phenylpentyl]-3-methyl-2-[2-oxotetrahydropyrimidin1(2H)-yl]butanamide ; (S)-N-((2S,4S,5S)-4-hydroxy-5-((R)-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamido)-1,6-diphenylhexan-2-yl)-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamide ;

Lopinavir EP Impurity - F - N-[(1S,2S,4S)-1-benzyl-4-(formylamino)-2-hydroxy-5-phenylpentyl]-2-(2,6-dimethylphenoxy)acetamide; Lopinavir N-Formylphenoxyacetamide (USP) ;

Lopinavir EP Impurity - G - N-[(1S,2S,4S)-(4-acetylamino)-1-benzyl-2-hydroxy-5- phenylpentyl]-2-(2,6-dimethylphenoxy)acetamide ;N-((2S,3S,5S)-5-acetamido-3-hydroxy-1,6-diphenylhexan-2-yl)-2-(2,6-dimethylphenoxy)acetamide ; LopinavirN-Acetylphenoxyacetamide(USP);

Lopinavir EP Impurity - I - (2S)-N-[(1S,2S,4S)-1-benzyl-4-[[2-(2,6-dimethylphenoxy)-acetyl]amino]-2-hydroxy-5-phenylpentyl]-3-methyl-2-[2-oxotetrahydropyrimidin-1(2H)-yl]butanamide ; Lopinavir Isomer / Isolopinavir ;

Lopinavir EP Impurity - N - (2S)-N-[(1S,3R,4S)-1-benzyl-4-[[2-(2,6-dimethylphenoxy)-acetyl]amino]-3-hydroxy-5-phenylpentyl]-3-methyl-2-[2-oxotetrahydropyrimidin-1(2H)-yl]butanamide ; (S)-N-{(2S,4R,5S)-5-[2-(2,6-Dimethylphenoxy)acetamido]-4-hydroxy-1,6-diphenylhexan-2-yl}-3-methyl-2-[2-oxotetrahydropyrimidin-1(2H)-yl]butanamide (as per USP);  Lopinavir (4R)-Epimer (USP) ;

Lopinavir EP Impurity - Q - N-[(1S,2S,4S)-1-benzyl-4-[[2-(2,6-dimethylphenoxy)-acetyl]amino]-2-hydroxy-5-phenylpentyl]-2-(2,6-dimethylphenoxy)acetamide ; N,N'-((2S,3S,5S)-3-hydroxy-1,6-diphenylhexane-2,5-diyl)bis(2-(2,6-dimethylphenoxy)acetamide) ; 

Lopinavir EP Impurity - R - (2S)-N-[(1S,3S,4S)-1-benzyl-4-[[2-(2,6-dimethylphenoxy)- acetyl]amino]-3-hydroxy-5-phenylpentyl]- 2-[3-[2-(2,6- dimethylphenoxy)acetyl]-2-oxotetrahydropyrimidin1(2H)-yl]-3-methylbutanamide;

Lopinavir EP Impurity - S - (1S,3S)-1-[(1S)-1-[[2-(2,6-dimethylphenoxy)acetyl]-amino]-2-phenylethyl]-3-[[(2S)-3-methyl-2-[2-oxotetrahydropyrimidin-1(2H)-yl]butanoyl]amino]-4-phenylbutyl 2-(2,6-dimethylphenoxy)acetate ;

Lopinavir EP Impurity - T - N,N'-bis[(1S,3S,4S)-1-benzyl-4-[[2-(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenylpentyl]urea ; N,N'-((2S,2'S,3S,3'S,5S,5'S)-(Carbonylbis(azanediyl))bis(3-hydroxy-1,6-diphenylhexane-5,2-diyl))bis(2-(2,6-dimethylphenoxy)acetamide); 

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Le lopinavir peut être utilisé lors des tests de validation des systèmes d'analyse chromatographique pour vérifier le bon fonctionnement du système HPLC. Dans les études comparatives de rétention (ECR), il sert de référence pour garantir la constance des temps de rétention, la résolution des pics et la reproductibilité de la méthode analytique.