Calcium folinate, also known as leucovorin calcium, is a reduced form of folic acid that supports DNA synthesis and repair and is used to reduce toxicity from folic acid antagonists like methotrexate while enhancing chemotherapy with 5-fluorouracil. Developed in the 1950s to treat folate-deficiency anemia, it later became essential in oncology as a “rescue” therapy, allowing high-dose methotrexate to target cancer cells safely and becoming a standard supportive treatment in both cancer and certain anemias.
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