Category
Empagliflozin
CAS Number
915095-89-5
Molecular Formula
C₁₇H₁₆BrClO₂
Molecular Weight
367.66 g/mol
Synonym

(3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]oxolane ; (S)-3-(4-(5-Bromo-2-chlorobenzyl)phenoxy)tetrahydrofuran ; (S)-4-Bromo-1-chloro-2-(4-tetrahydrofuran-3-yloxy-benzyl)-benzene ; (3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran ; Empagliflozin Bromo Impurity ; Empagliflozin Impurity I;Furan,3-[4-[(5-bromo-2-chlorophenyl)methyl]phenoxy]tetrahydro-,(3S); (3S)-3-[4-[(5-bromo-2-chlorophenyl)methyl]phenoxy]oxolane

Keywords
Aromatics
Heterocycles
Pharmaceutical Standards
Intermediates
Fine Chemicals
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Empagliflozin bromo impurity refers to a specific chemical impurity that can occur during the synthesis of empagliflozin, a drug used to treat type 2 diabetes. This impurity typically arises when a bromine-containing intermediate or reagent reacts unintentionally, leading to trace amounts of brominated by-products in the final drug substance. Such impurities are important to monitor because regulatory guidelines (like ICH Q3A/B) require control of potentially genotoxic or harmful impurities to ensure drug safety and quality. Analytical methods like HPLC or LC-MS are commonly used to detect and quantify this impurity.