Category
Bortezomib
CAS Number
289472-78-2
Molecular Formula
C19H24N4O3
Molecular Weight
356.4 g/mol
Synonym

N-[(2S)-1-[[(1R)-1-hydroxy-3-methylbutyl]amino]-1-oxo-3-phenylpropan-2-yl]pyrazine-2-carboxamide; N-((S)-1-(((R)-1-Hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide; (R)-Hydroxy Des(boric Acid) Bortezomib; (R)-Hydroxy Des(boric Acid) Bortezomib; N-[(1S)-2-[[(1R)-1-Hydroxy-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-2-pyrazinecarboxamide; Bortezomib Hydroxy Impurity (1R,2S)-Isomer; N-[(1S)-2-[[(1R)-1-hydroxy-3-methylbutyl]amino]-2-oxo-1-(phenylmethyl)ethyl]pyrazinecarboxamide; Pyrazine-2-carboxylic acid [1-(1-hydroxy-3-methyl- butylcarbamoyl)-2-phenyl-ethyl]-amide; N-((S)-1-(((R)-1-hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide; (S,R)-Bortezomib Hydroxyisopentyl Amide Analog (USP)

Keywords
Fine Chemicals
Pharmaceutical Standards
Metabolites.
Impurities
Intermediates
slide.1
Purity:

Above - 95.0%

Technical Data:

We will provide complete documentation support for every Standard Material. All analytical reports such as ¹H NMR, ¹³C NMR, Mass, FT-IR, HPLC Purity/GC Purity/QNMR Purity, Water content by KF/ Loss on Drying/TGA (Thermo-gravimetric Analysis). Certificate of Analysis with potency report. Each Standard Material SER (Structure Elucidation Report) with NMR, Mass, IR spectral interpretation. This whole analytical document can be included in eCTD, ANDA, DMF submissions to regulatory agencies.

(S,R)-Bortezomib Hydroxyisopentyl Amide Analog is a stereochemically defined bortezomib derivative in which the amide side chain is modified to a hydroxyisopentyl group, aiming to retain proteasome inhibition while potentially improving pharmacological properties such as stability, selectivity, or reduced toxicity.