Atorvastatin 2-Hydroxy Lactone

Atorvastatin 2-Hydroxy Lactone is a metabolite impurity related to Atorvastatin, a widely used HMG-CoA reductase inhibitor for the treatment of hypercholesterolemia and cardiovascular diseases. The compound is the lactone form of 2-hydroxy atorvastatin, formed via metabolic conversion. It has a CAS Number: 163217-74-1; molecular formula of C₃₃H₃₃FN₂O₅ and a molecular weight of 556.6 g/mol. As a metabolite impurity, Atorvastatin 2-Hydroxy Lactone is evaluated under global regulatory frameworks such as ICH guidelines for impurity profiling, safety assessment, and stability studies. It plays an important role in understanding drug metabolism, pharmacokinetics, and potential safety implications, including its relevance in statin-associated effects.

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