Orphenadrine is a centrally acting muscle relaxant with both analgesic and anticholinergic properties, commonly used to relieve muscle pain, stiffness, and spasms associated with musculoskeletal conditions. Chemically related to diphenhydramine, it was initially developed in the 1940s–1950s for the treatment of Parkinson’s disease due to its anticholinergic effects. Over time, its muscle relaxant and pain-relieving properties were recognized, leading to its widespread use in orthopedic and neurological disorders. Orphenadrine is available in various formulations, including oral tablets, injectables, and combination therapies, often paired with acetaminophen to enhance analgesic effects.
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