Glycopyrronium, also known as glycopyrrolate, is a synthetic anticholinergic drug that blocks acetylcholine at muscarinic receptors, reducing secretions in the respiratory and gastrointestinal tracts and other tissues, making it useful in managing COPD, excessive salivation, and as a pre-anesthetic agent. Developed in the 1960s to provide safer and more selective anticholinergic effects, it was found to reduce secretions effectively while minimizing central nervous system side effects compared to earlier agents. Over time, glycopyrronium has become a versatile and well-established drug in clinical practice, valued for its efficacy, safety, and predictable pharmacological profile across multiple therapeutic applications.
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