Diphenoxylate is a synthetic opioid derivative primarily used as an antidiarrheal agent. It works by slowing intestinal motility, allowing for increased water and electrolyte absorption from the intestines. Diphenoxylate is often combined with atropine to discourage abuse and enhance its antidiarrheal effect. It is commonly administered orally in tablet or liquid form. The drug is effective in managing acute and chronic diarrhea caused by various conditions. Diphenoxylate is used in both adults and children under careful medical supervision. It helps reduce the frequency and urgency of bowel movements. The combination with atropine also reduces the risk of opioid dependence. Diphenoxylate is not recommended for diarrhea caused by certain infections like Clostridium difficile. Overall, it plays a significant role in controlling symptomatic diarrhea and improving patient comfort.
