Dimenhydrinate is a first-generation antihistamine and anti-emetic drug composed of diphenhydramine and 8-chlorotheophylline, commonly marketed under brand names like Dramamine and Gravol. It was introduced into medical use around 1949 and is widely used to prevent and treat nausea, vomiting, dizziness, and motion sickness by blocking histamine H₁ receptors and reducing vestibular stimulation in the inner ear. Dimenhydrinate calms the brain’s balance centers, making it effective for motion-related discomfort and vertigo, though drowsiness is a common side effect. It is available over-the-counter in oral and injectable forms and remains a staple in both self-care and clinical settings for managing motion sickness and related symptoms.
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