Trigeminovascular system is a neurovascular network formed by the trigeminal nerve and meningeal blood vessels that plays a central role in the generation and transmission of migraine pain. When activated, trigeminal sensory fibers release vasoactive neuropeptides such as calcitonin gene-related peptide (CGRP), substance P, and neurokinin A, leading to dilation of cerebral vessels, neurogenic inflammation, and sensitization of pain pathways in the brainstem and cortex. This system is considered a key mechanism underlying migraine attacks, and it is a major therapeutic target for modern anti-migraine drugs like CGRP inhibitors and triptans.