Category
Voriconazole
CAS Number
137234-76-5
Molecular Formula
C₁₆H₁₃ClF₃N₅O
Molecular Weight
383.76 g/mol
Synonym

rel-(2R,3R)-3-(6-Chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol; rel-(αR,βR)-6-Chloro-α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol

Keywords
Fine Chemicals
Pharmaceutical Standards
Metabolites.
Impurities
Intermediates
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Voriconazole (2R,3R)-Isomer refers to a specific stereoisomer of voriconazole in which the two chiral centers have the (2R,3R) absolute configuration. It is a stereochemical variant of the drug that may form during synthesis or chiral interconversion. In pharmaceutical quality control, this isomer is monitored as a stereoisomeric impurity because different configurations can show differences in antifungal activity, pharmacokinetics, and safety. Controlling such isomers ensures the product meets strict enantiomeric purity requirements as per pharmacopeial standards.