Category
Regorafenib
CAS Number
755037-03-7
Molecular Formula
C21H15ClF4N4O3
Molecular Weight
482.82 g/mol
Synonym

4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide;4-[4-[N'-(4-Chloro-3-trifluoromethylphenyl)ureido]-3-fluorophenoxy]pyridine-2-carboxylic Acid Methylamide;4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide;4-[4-[N'-(4-Chloro-3-trifluoromethylphenyl)ureido]-3-fluorophenoxy]pyridine-2-carboxylic Acid Methylamide;

Keywords
Amines
Aromatics
Pharmaceutical Standards
Intermediates
Fine Chemicals
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Regorafenib is an oral multi-kinase inhibitor used to treat metastatic colorectal cancer, gastrointestinal stromal tumors, and hepatocellular carcinoma after failure of prior therapies. It works by blocking multiple signaling pathways involved in tumor growth, angiogenesis, and metastasis. Common side effects include fatigue, hypertension, diarrhea, and hand–foot skin reactions.