Category
Minocycline
CAS Number
Minocycline STD - 10118-90-8 : IMP - A - 43168-51-0 : IMP - B - 808-26-4 : IMP - C - 4708-96-7 : IMP - E - 864073-42-7 : IMP - F -1075240-33-3 : IMP - G - 601455-95-2 : IMP - H - 1346598-44-4 ;
Alternate CAS Number
13614-98-7(HCl Salt) , 128420-71-3(HCl Dihydrate)
Molecular Formula
Minocycline STD - C23H27N3O7 : IMP - A - C23H27N3O7 : IMP - B - C21H22N2O7 : IMP - C - C22H25N3O7 : IMP - E : IMP - F - C24H29N3O8 : IMP - G - C25H32N4O7 : IMP - H - C23H25N3O7 ;
Molecular Weight
Minocycline STD - 457.48 g/mol : IMP - A - 457.48 g/mol : IMP - B - 414.41 g/mol : IMP - C - 443.45 g/mol : IMP - E - 456.5 g/mol : IMP - F - 487.50 g/mol: IMP - G - 500.54 g/mol : IMP - H - 455.46 g/mol ;
Synonym

Minocycline - (4S,4aS,5aR,12aS)-4,7-Bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide ; (2E,4S,4aR,5aS,12aR)-2-(Amino-hydroxy-methylidene)-4,7-bis(dimethylamino)-10,11,12a-trihydroxy-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione ;

Minocycline EP Impurity A - (4R,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12atetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12aoctahydrotetracene-2-carboxamide ;

Minocycline EP Impurity B - (4S,4aS,5aR,12aS)-4-(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide ;

Minocycline EP Impurity C - (4S,4aS,5aR,12aS)-4-(dimethylamino)-3,10,12,12atetrahydroxy-7-(methylamino)-1,11-dioxo1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide ;

Minocycline EP Impurity E - (4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12a-trihydroxy-12-imino-1,11-dioxo1,4,4a,5,5a,6,11,11a,12,12a-decahydrotetracene-2-carboxamide;

Minocycline EP Impurity F - (4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12atetrahydroxy-N-(hydroxymethyl)-1,11-dioxo1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide ;

Minocycline EP Impurity G - (4S,4aS,5aR,12aS)-4,7,9-tris(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide ; 

Minocycline EP Impurity H -  (4S,4aS,12aS)-4,7-bis(dimethylamino)-3,10,11,12atetrahydroxy-1,12-dioxo-1,4,4a,5,12,12ahexahydrotetracene-2-carboxamide ; 

Purity:

Above - 95.0%

Technical Data:

We will provide complete documentation support for every Standard Material. All analytical reports such as ¹H NMR, ¹³C NMR, Mass, FT-IR, HPLC Purity/GC Purity/QNMR Purity, Water content by KF/ Loss on Drying/TGA (Thermo-gravimetric Analysis). Certificate of Analysis with potency report. Each Standard Material SER (Structure Elucidation Report) with NMR, Mass, IR spectral interpretation. This whole analytical document can be included in eCTD, ANDA, DMF submissions to regulatory agencies.

Minocycline is used as a certified reference standard (CRS) for system suitability testing to ensure the accuracy, precision, and reliability of analytical methods. It helps evaluate chromatographic parameters such as retention time, peak shape, and resolution in pharmaceutical analysis.