Category
Fludarabine
CAS Number
21679-14-1
Alternate CAS Number
75607-67-9(Phosphate salt)
Molecular Formula
C10H12FN5O4
Molecular Weight
285.24 g/mol
Synonym

(2R,3S,4S,5R)-2-(6-amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; 9-β-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine; 2-Fluoro-9-β-D-arabinofuranosyladenine;2-Fluoroadenine Arabinoside; (2R,3S,4S,5R)-2-(6-amino-2-fluoro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol; Adenine,9-β-D-arabinofuranosyl-2-fluoro; 9-b-D-Arabinofuranosyl-2-fluoroadenine; NSC 118218; NSC 118218H

Keywords
Impurities
Metabolites.
Pharmaceutical Standards
Intermediates
Fine Chemicals
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Purity:

Above - 95.0%

Technical Data:

We will provide complete documentation support for every Standard Material. All analytical reports such as ¹H NMR, ¹³C NMR, Mass, FT-IR, HPLC Purity/GC Purity/QNMR Purity, Water content by KF/ Loss on Drying/TGA (Thermo-gravimetric Analysis). Certificate of Analysis with potency report. Each Standard Material SER (Structure Elucidation Report) with NMR, Mass, IR spectral interpretation. This whole analytical document can be included in eCTD, ANDA, DMF submissions to regulatory agencies.

Fludarabine is considered a standard chemotherapeutic agent in the treatment of chronic lymphocytic leukemia (CLL) and certain indolent non-Hodgkin lymphomas due to its proven effectiveness in inhibiting DNA synthesis in malignant lymphocytes. It is commonly used alone or in combination regimens, such as with cyclophosphamide and monoclonal antibodies, and also plays an important role in conditioning protocols for stem cell transplantation, making it a well-established standard drug in hematologic malignancy management.