Category
Apixaban
CAS Number
1801881-15-1
Molecular Formula
C₁₁H₁₁ClN₂O
Molecular Weight
222.67 g/mol
Synonym

1-(4-Aminophenyl)-3-chloro-5,6-dihydropyridin-2(1H)-one; 1-(4-Aminophenyl)-3-chloro-5,6-dihydro-2(1H)-pyridinone; 2(1H)-Pyridinone,1-(4-aminophenyl)-3-chloro-5,6-dihydro

Keywords
Aromatics
Heterocycles
Enzyme inhibitors
Pharmaceutical Standards
Fine Chemicals
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The chloro amine impurity in Apixaban is a trace by-product that can form during the synthesis of Apixaban, often due to incomplete substitution or side reactions involving chloro and amine functional groups. This impurity is important because even low levels may affect the drug’s purity, safety, and stability. Therefore, it is carefully monitored and controlled using analytical techniques such as HPLC or LC-MS to ensure compliance with pharmaceutical quality and regulatory standards.