Category
Apixaban
CAS Number
NA
Molecular Formula
C₂₆H₂₈N₆O₆
Molecular Weight
520.54 g/mol
Synonym

Methyl 5-((4-(3-carbamoyl-1-(4-methoxyphenyl)-7-oxo-4,5-dihydro-1H-pyrazolo[3,4-c]pyridin-6(7H)-yl)phenyl)(nitroso)amino)pentanoate

Keywords
Impurities
Amines
Nitrosamine
N-Nitrosamines Impurities manufacturers and Suppliers in Hyderabad India
slide.1

Apixaban Amide Methyl Ester Nitroso Impurity is a potentially genotoxic impurity that can form during the synthesis or degradation of apixaban. It contains a nitroso group (–N=O) attached to the amide methyl ester moiety. Because nitroso compounds are often carcinogenic, regulatory agencies like the FDA and EMA require its presence to be controlled at trace levels (ppm).