Category
Abemaciclib
CAS Number
1231930-57-6
Molecular Formula
C₂₅H₂₈F₂N₈
Molecular Weight
478.55 g/mol
Synonym

5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(5-(piperazin-1-ylmethyl)pyridin-2-yl)pyrimidin-2-amine ; 5-Fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-N-[5-(1-piperazinylmethyl)-2-pyridinyl]-2-pyrimidinamine ; Abemaciclib Metabolites M2 ; Des Ethyl Abemaciclib;

Keywords
Pharmaceutical Standards
Intermediates
Fine Chemicals
Impurities manufacturer and Suppliers in Hyderabad india
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Purity:

Above - 95.0%

Technical Data:

We will provide complete documentation support for every Standard Material. All analytical reports such as ¹H NMR, ¹³C NMR, Mass, FT-IR, HPLC Purity/GC Purity/QNMR Purity, Water content by KF/ Loss on Drying/TGA (Thermo-gravimetric Analysis). Certificate of Analysis with potency report. Each Standard Material SER (Structure Elucidation Report) with NMR, Mass, IR spectral interpretation. This whole analytical document can be included in eCTD, ANDA, DMF submissions to regulatory agencies.

Abemaciclib Metabolite M2 is one of the active metabolites of Abemaciclib formed during its biotransformation in the body, and it retains pharmacological activity by contributing to the inhibition of cyclin-dependent kinases (CDK4 and CDK6). It plays an important role in the overall therapeutic effect of the drug, particularly in the treatment of Breast Cancer, and is commonly studied in pharmacokinetic and metabolism research to understand efficacy and safety.