Permethrin is a synthetic chemical belonging to the pyrethroid class of insecticides, widely used for its potent insecticidal and acaricidal properties. It acts on the nervous system of insects, causing prolonged depolarization of neurons, which leads to paralysis and death. Originally developed in the 1970s as part of efforts to create more stable and effective derivatives of natural pyrethrins compounds extracted from chrysanthemum flowers permethrin quickly gained attention for its broad-spectrum activity, low mammalian toxicity, and environmental stability. Over time, it has found diverse applications, ranging from agricultural pest control and public health programs to medical uses, such as treatment of scabies and lice. Its introduction marked a significant advance in insecticide chemistry, combining the natural potency of pyrethrins with synthetic modifications that enhanced longevity and efficacy, making it a cornerstone in both vector control and personal protection strategies.
