Gonadorelin is a synthetic decapeptide that mimics natural gonadotropin-releasing hormone (GnRH) and stimulates the anterior pituitary to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH), essential for regulating reproduction, including ovulation in females and testosterone production in males. Developed in the 1970s with advances in peptide synthesis, it was created as a reliable alternative to natural GnRH for clinical and research use. Clinically, gonadorelin is used for diagnosing pituitary gonadotropin deficiency, evaluating delayed puberty, managing infertility, and controlled ovarian stimulation, making it a valuable tool in reproductive endocrinology while also paving the way for longer-acting GnRH analogs.
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