Etacrynic acid is a potent loop diuretic that increases urine output by inhibiting sodium and chloride reabsorption in the loop of Henle in the kidneys. It is unique among loop diuretics because it does not contain a sulfonamide group, making it suitable for patients who are allergic to sulfa drugs. The medication acts rapidly and can be administered orally or intravenously depending on the clinical need. It is primarily used to treat edema (fluid retention) associated with conditions such as congestive heart failure, liver cirrhosis, and kidney disorders. Etacrynic acid helps reduce swelling and fluid overload in the body and may be prescribed when other diuretics are ineffective. It is marketed under the brand name Edecrin. Careful monitoring is necessary during treatment because it can cause electrolyte imbalance, dehydration, and other side effects.
