Enoxolone, also known as glycyrrhetinic acid, is a biologically active compound derived from glycyrrhizin in licorice root (Glycyrrhiza glabra) and is known for its anti-inflammatory, anti-ulcer, and corticosteroid-like effects. It has been used in the treatment of peptic ulcers, gastric inflammation, and certain dermatological conditions by inhibiting 11β-hydroxysteroid dehydrogenase, thereby prolonging the action of endogenous corticosteroids. Developed and scientifically studied in the mid-20th century, particularly during the 1950s–1960s, enoxolone gained clinical importance after research confirmed its ulcer-healing properties. Although its systemic use is limited due to possible side effects such as sodium retention and hypertension, it remains a valuable compound in pharmacology and represents an important example of a natural product adapted for modern therapeutic use.
