Dosulepin (also called dothiepin) is a tricyclic antidepressant introduced in the 1960s for the treatment of depression, particularly when associated with anxiety. It works by blocking the reuptake of serotonin and norepinephrine, helping to improve mood and emotional balance. Widely prescribed during the 1970s and 1980s, especially in the UK, it was later used for conditions such as neuropathic pain. However, due to concerns about toxicity in overdose and potential cardiac side effects, its use declined with the availability of safer alternatives like SSRIs, and it is now less commonly recommended as a first-line therapy.
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