Dipyridamole is a pharmacological agent primarily used for its antiplatelet and vasodilatory effects. It works by inhibiting the uptake of adenosine into platelets, endothelial cells, and erythrocytes, which increases local concentrations of adenosine and leads to vasodilation. Dipyridamole also inhibits phosphodiesterase, resulting in elevated cyclic AMP levels in platelets and reduced platelet aggregation. It is commonly prescribed to prevent thromboembolic events, especially in patients with a history of stroke or transient ischemic attacks. The drug is often used in combination with other antiplatelet agents, such as aspirin, to enhance efficacy. Dipyridamole can be administered orally or intravenously, depending on the clinical need. It was first developed in the 1960s and has since become a standard therapy in cardiovascular medicine. Its vasodilatory properties are also utilized in diagnostic procedures like stress testing. Dipyridamole is generally well-tolerated, though side effects may include headache, dizziness, or gastrointestinal discomfort. Today, it remains an important drug in the prevention of thrombotic disorders and in cardiovascular diagnostics.
