Dipivefrine is a synthetic sympathomimetic drug used mainly in ophthalmology. It is a prodrug of epinephrine, designed to penetrate the cornea more effectively. After entering the eye, dipivefrine is converted into epinephrine by ocular enzymes. This conversion helps reduce intraocular pressure by decreasing aqueous humor production and increasing its outflow. Dipivefrine is primarily used in the treatment of open-angle glaucoma. It is also used in cases of ocular hypertension. Compared to epinephrine, it causes fewer local side effects. The drug is administered as eye drops. Dipivefrine improves patient tolerance and compliance. Its use helps prevent optic nerve damage and vision loss in glaucoma patients.
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