Dienogest is a synthetic progestin used mainly for treatment of endometriosis and as part of hormonal contraceptives. It works by suppressing ovarian estrogen production and altering endometrial tissue, reducing pain and lesions associated with endometriosis. Dienogest was first developed in the 1970s–1980s during research into selective progestins with improved safety and tolerability, and it gained approval in the 1990s–2000s for clinical use. Over the years, it has become a preferred option due to its strong progestogenic effect with minimal androgenic activity, making it effective in managing gynecological disorders while maintaining a favorable safety profile.
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