Clotrimazole is a broad-spectrum antifungal drug widely used to treat fungal infections of the skin and mucous membranes. It belongs to the imidazole class of antifungal agents. Clotrimazole works by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes. This disruption leads to increased membrane permeability and cell death. It is effective against dermatophytes, yeasts, and molds. Clotrimazole is commonly available in topical forms such as creams, lotions, and powders. It is also used as vaginal tablets or creams for the treatment of candidiasis. The drug is well tolerated with minimal systemic absorption when applied topically. Side effects are usually mild and localized. Due to its safety and efficacy, clotrimazole is widely used in clinical practice.
