Buflomedil is a vasoactive drug developed in the mid-20th century to improve blood flow in peripheral arterial diseases by dilating blood vessels and enhancing circulation. Historically, it became popular in Europe for treating conditions like intermittent claudication and peripheral vascular insufficiency, representing an early pharmacological approach to circulatory disorders. Over time, its use declined in many countries due to concerns about cardiovascular side effects, including arrhythmias, but it remains significant as a milestone in the development of therapies for vascular insufficiency.
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