Amidotrizoic acid is a water-soluble, iodinated contrast agent used primarily in radiographic imaging to enhance the visibility of vascular structures, urinary tract, and gastrointestinal organs during X-ray and CT procedures. It works by increasing the radiodensity of the blood or luminal contents, allowing improved contrast between tissues and organs. Developed in the mid-20th century as part of efforts to create safer and more effective contrast media than earlier ionic and poorly soluble agents, amidotrizoic acid became widely used due to its high water solubility, rapid renal excretion, and relatively low toxicity. Over time, it has been formulated in various concentrations and combinations for intravenous, intra-arterial, or gastrointestinal administration, remaining an important diagnostic tool in medical imaging while requiring careful monitoring for hypersensitivity or renal adverse effects.
