Sofosbuvir Phosphate Impurity

Category

Sofosbuvir

CAS Number

1520010-86-9

Molecular Formula

C12H17NNaO5P

Molecular Weight

309.23

Catelogue Number

MLS-SOF-IH-IMP-SP/01

Synonym

N-(Hydroxyphenoxyphosphinyl)-L-alanine 1-Methylethyl Ester Sodium Salt|N-(Hydroxyphenoxyphosphinyl)-L-alanine 1-Methylethyl Ester Sodium Salt;|N-(Hydroxyphenoxyphosphinyl)-L-alanine 1-Methylethyl Ester Sodium Salt.|Sofosbuvir Phosphate Impurity ; Isopropyl N-(Hydroxyphenoxyphosphinyl)alaninate sodium salt ;

Keywords

Heterocycles

Impurities

Nucleotides

Bases & Related Reagents

Pharmaceuticals

Intermediates & Fine Chemicals

Sofosbuvir (R)-Phosphate is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2’-deoxy-2’-α-fluoro-β-C-methyluridine-5’-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.

Sofosbuvir Phosphate Impurity

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