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Category
Sofosbuvir
CAS Number
NA
Molecular Formula
C22H29FN3O9P
Molecular Weight
529.45
Catelogue Number
MLS-SOFWS/01
Synonym
Isopropyl (2S)-2-[[[(2R,3R,4R,5S)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyl-tetrahydrofuran-2-yl]methoxy-phenoxy-phosphoryl] amino] propanoate ;
Keywords
Heterocycles
Impurities
Nucleotides
Bases & Related Reagents
Pharmaceuticals
Intermediates & Fine Chemicals
Sofosbuvir (R)-Phosphate is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2’-deoxy-2’-α-fluoro-β-C-methyluridine-5’-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.