1-Cyclopentyl-4-nitrosopiperazine (CPNP)

N-Nitroso 1-Cyclopentylpiperazine (CPNP), also referred to as 1-cyclopentyl-4-nitrosopiperazine or Piperazine, 1-cyclopentyl-4-nitroso- (9CI), is a genotoxic and potentially carcinogenic nitrosamine impurity that may form in piperazine-derived drug substances when secondary amine functionalities react with nitrosating agents under acidic, oxidative, or nitrite-contaminated conditions. Formation of CPNP can occur during API synthesis, processing, or degradation, especially when precursors containing secondary amines are exposed to nitrosation-prone environments.CAS.No: 61379-66-6; Molecular formula: C9H17N3O; Molecular weight: 183.26.

Manasa Life Sciences manufactures nitrosamine impurities in Hyderabad, India, and supplies products to markets across Asia, Europe, Africa, the GCC, and the UAE, ensuring reliable delivery, full traceability, and Good Documentation Practices (GDP) for nitrosamine impurities. And also we support complete nitrosamine-control readiness by supplying certified nitrosamine impurity reference standards, conducting in-depth risk assessments, and developing and validating ultra-sensitive LC-MS/MS and GC-MS analytical methods. Our solutions enable accurate detection, quantification, and control of nitrosamine impurities whether theoretical, synthesis-related, or degradation-derived helping manufacturers meet USP-relevant expectations, maintain strict global regulatory compliance, and safeguard patient safety.