Category
Midazolam
CAS Number
Midazolam STD - 59467-70-8 : IMP - A - 59468-07-4 : IMP - B - 59469-74-8 : IMP - E - 59467-64-0 : IMP - G - 59467-86-6 : IMP - H - 119401-13-7 ;
Molecular Formula
Midazolam STD - C18H13ClFN3 : IMP - A - C18H15ClFN3 : IMP - B - C18H13ClFN3 : IMP - E - C16H15ClFN3 : IMP - G - C18H14ClN3 : IMP - H - C15H10ClFN2 ;
Molecular Weight
Midazolam STD - 325.77 g/mol : IMP - A - 327.78 g/mol : IMP - B - 325.77 g/mol : IMP - E - 303.8 g/mol : IMP - G - 307.8 g/mol : IMP - H - 272.7 g/mol ;
Synonym

Midazolam - 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine ; 4H-Imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6-(2-fluorophenyl)-1-methyl;

Midazolam EP Impurity A - (6RS)-8-chloro-6-(2-fluorophenyl)-1-methyl-5,6-dihydro4H-imidazo[1,5-a][1,4]benzodiazepine ; 8-Chloro-6-(2-fluorophenyl)-1-methyl-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine; 

Midazolam EP Impurity B - (6RS)-8-chloro-6-(2-fluorophenyl)-1-methyl-6H-imidazo-[1,5-a][1,4]benzodiazepine ; 

Midazolam EP Impurity E -  [(2RS)-7-chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-yl]methanamine ; (7-Chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-2-yl)methanamine ;

Midazolam EP Impurity G - 8-chloro-1-methyl-6-phenyl-4H-imidazo-[1,5-a][1,4]benzodiazepine ; 8-Chloro-1-methyl-6-phenyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepine; Desfluoromidazolam ;

Midazolam EP Impurity H - 6-Chloro-2-methyl-4-(2-fluorophenyl)quinazoline; 6-Chloro-4-(2-fluorophenyl)-2-methylquinazoline ; 

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Purity:

Above - 95.0%

Technical Data:

We will provide complete documentation support for every Standard Material. All analytical reports such as ¹H NMR, ¹³C NMR, Mass, FT-IR, HPLC Purity/GC Purity/QNMR Purity, Water content by KF/ Loss on Drying/TGA (Thermo-gravimetric Analysis). Certificate of Analysis with potency report. Each Standard Material SER (Structure Elucidation Report) with NMR, Mass, IR spectral interpretation. This whole analytical document can be included in eCTD, ANDA, DMF submissions to regulatory agencies.

Midazolam is used as a certified reference standard (CRS) in system suitability testing to ensure the accuracy, precision, and reliability of analytical methods. It helps assess chromatographic performance by evaluating parameters such as retention time, peak symmetry, and resolution in pharmaceutical analysis.