Category
Metolazone
CAS Number
Metolazone - 17560-51-9 : IMP - A - 50869-25-5 : IMP - B - 28508-63-6 : IMP - C - 28524-40-5 : IMP - D - 4015-23-0 : IMP - E - 23380-54-3 :
Molecular Formula
Metolazone - C16H16ClN3O3S : IMP - A - C16H16ClN3O3S : IMP - B - C16H16ClN3O3S : IMP - C - C15H14ClN3O3S : IMP - D - C16H14ClN3O3S : IMP - E - C14H14ClN3O3S
Molecular Weight
Metolazone - 365.8 g/mol : IMP - A - 365.83 g/mol : IMP - B - 365.83 g/mol : IMP - C - 351.81 g/mol : IMP - D - 363.82 g/mol : IMP - E - 339.8 g/mol
Synonym

Metolazone - (2RS)-7-Chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide; -Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide; 2-Methyl-3-(o-tolyl)-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone; 7-Chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide; 6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-; 7-Chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamide ;

Metolazone EP Impurity A - (2RS)-7-Chloro-2-methyl-3-(3-methylphenyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulphonamide ; 7-Chloro-2-methyl-3-(3-methylphenyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulfonamide ;

Metolazone EP Impurity B - 7-chloro-2-methyl-4-oxo-3-(p-tolyl)-1, 2, 3, 4-tetrahydroquinazoline-6-sulfonamide ; (2RS)-7-Chloro-2-methyl-3-(4-methylphenyl)-4-oxo-1,2,3,4-tetrahydroquinazoline-6-sulphonamide ;

Metolazone EP Impurity C - (2RS)-7-chloro-2-methyl-4-oxo-3-phenyl1,2,3,4-tetrahydroquinazoline-6-sulfonamide ; 7-Chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-phenyl-6-quinazolinesulfonamide;

Metolazone EP Impurity D - 7-Chloro-2-methyl-3-(2-methylphenyl)-4-oxo-3,4-dihydroquinazoline-6-sulfonamide; 6-Quinazolinesulfonamide, 7-chloro-3,4-dihydro-2-methyl-3-(2-methylphenyl)-4-oxo-;

Metolazone EP Impurity E - 2-Amino-4-chloro-N-(2-methylphenyl)-5-sulfamoylbenzamide ; Metolazone USP Related Compound B ; Metolazone benzamide analog; 2-amino-5-(aminosulfonyl)-4-chloro-N-(2-methylphenyl)- ;

slide_1

Metolazone is used as a system suitability Chemical Reference Standard (CRS) to evaluate and validate the performance of analytical systems in pharmaceutical testing. It ensures accuracy, precision, and reproducibility of methods such as HPLC during routine quality control analysis.