Category
Loperamide
CAS Number
Loperamide STD - 53179-11-6 : IMP - A - 1391052-94-0 : IMP - B - 2575516-62-8 : IMP - D - 37743-41-2 : IMP - E - 1426322-82-8: IMP - G - 109572-89-6 : IMP - H - 61299-42-1 :
Alternate CAS Number
Loperamide STD - 34552-83-5(HCl Salt)
Molecular Formula
Loperamide STD - C29H33ClN2O2 : IMP - A - C35H37ClN2O2 : IMP - B - C47H53ClN3O3 : IMP - D - C29H35ClN2O2 : IMP - E - C38H40Cl2N2O3 : IMP - G - C29H33ClN2O3 : IMP - H - C29H31ClN2O
Molecular Weight
Loperamide STD - 477.04 g/mol : IMP - A - 553.13 g/mol : IMP - B - 743.39 g/mol : IMP - D - 442.59 g / mol : IMP - E - 493.04 g/mol : IMP - G - 493.04 g/mol : IMP - H - 459.02 g/mol :
Synonym

Loperamide - 4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N,N-dimethyl-2,2-diphenylbutanamide ; 4-[4-Chlorophenyl]-4-hydroxy-N,N-dimethyl-alpha,alpha-Diphenyl-1-piperidinebutanamide ; 

Loperamide EP Impurity - A -  4-[4-(4'-chloro-[1,1'-biphenyl]-4-yl)-4-hydroxypiperidin1-yl]-N,N-dimethyl-2,2-diphenylbutanamide ; 4-(4-(4'-Chloro-[1,1'-biphenyl]-4-yl)-4-hydroxypiperidin-1-yl)-N,N-dimethyl-2,2-diphenylbutanamide; 

Loperamide EP Impurity - B -  4-(4-chlorophenyl)-1,1-bis[4-(dimethylamino)-4-oxo-3,3-diphenylbutyl]-4-hydroxypiperidin-1-ium ; Piperidinium,4-(4-chlorophenyl)-1,1-bis[4-(dimethylamino)-4-oxo-3,3-diphenylbutyl]-4-hydroxy ;

Loperamide EP Impurity - D - 4-(4-hydroxy-4-phenylpiperidin-1-yl)-N,N-dimethyl-2,2-diphenylbutanamide ;  Deschloroloperamide;

Loperamide EP Impurity - E - 1,4-bis[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-2,2-diphenylbutan-1-one ; 4-(4-Chlorophenyl)-1-[4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-2,2-diphenylbutanoyl]piperidin-4-ol ; 

Loperamide EP Impurity - G -  cis-4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-a,a-diphenyl-1-piperidinebutanamide 1-Oxide ; (1s,4r)-4-(4-Chlorophenyl)-1-(4-(dimethylamino)-4-oxo-3,3-diphenylbutyl)-4-hydroxypiperidine 1-oxide; 4-[cis-4-(4-Chlorophenyl)-4-hydroxy-1-oxidopiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide ;  Loperamide cis-N-Oxide ;

Loperamide EP Impurity - H - 4-[4-(4-chlorophenyl)-3,6-dihydropyridin-1(2H)-yl]-N,N-dimethyl-2,2-diphenylbutanamide ; 4-(4-(4-Chlorophenyl)-3,6-dihydropyridin-1(2H)-yl)-N,N-dimethyl-2,2-diphenylbutanamide ; Dehydro Loperamide ; Anhydroloperamide ;

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Loperamide can be used in system suitability testing in chromatographic methods to verify the reliability and performance of the analytical system. In Comparative Retention Studies (CRS), it serves as a reference compound to ensure consistent retention times, peak resolution, and reproducibility.