Category
Itraconazole
CAS Number
Itraconazole STD : 84625-61-6 ; IMP- B : 854372-77-3 ; IMP-C : 74855-91-7 ; IMP-D:89848-49-7 ; IMP-E: 252964-65-1;IMP-F : 89848-51-1 ; IMP-G: NA ;
Molecular Formula
Itraconazole STD : C35H38Cl2N8O4 ; IMP-B : C35H38Cl2N8O4 : IMP-C : C34H36Cl2N8O4 ;IMP-D:C34H36Cl2N8O4 ; IMP-E: C35H38Cl2N8O4 ;IMP-F : C35H38Cl2N8O4 ; IMP-G : C44H41Cl4N11O6;
Molecular Weight
Itraconazole STD : 705.6 g/mol ; IMP-B : 705.6 g/mol ;IMP-C : 691.6 g/mol ;IMP-D:691.6 g/mol ; IMP-E: 705.6 g/mol ;IMP-F : 705.6 g/mol ; IMP-G : 961.7 g/mol
Synonym

Itraconazole : 4-(4-(4-(4-((2-((1H-1,2,4-triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-(sec-butyl)-1H-1,2,4-triazol-5(4H)-one ;

Itraconazole EP Impurity B : 4-[4-[4-[4-[[cis-2-(2,4-dichlorophenyl)-2-(4H-1,2,4-triazol-4-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(1RS)-1-methylpropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one;

Itraconazole EP Impurity C : 4-[4-[4-[4-[[cis-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-propyl-2,4-dihydro-3H-1,2,4-triazol-3-one;

Itraconazole EP Impurity D :4-[4-[4-[4-[[cis-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-(1-methylethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one ;

Itraconazole EP Impurity E : 4-[4-[4-[4-[[trans-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(1RS)-1-methylpropyl]-2,4-dihydro-3H-1,2,4-triazol- 3-one ;

Itraconazole EP Impurity F : 2-butyl-4-[4-[4-[4-[[cis-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one ; 

Itraconazole EP Impurity G : 4-[4-[4-[4-[[cis-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[[cis-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one ;

slide.1

Itraconazole is used in chromatographic system suitability testing to ensure the system performs reliably, providing consistent retention time, resolution, and reproducibility. It helps evaluate key parameters such as theoretical plates, tailing factor, and %RSD of peak area, confirming the system is fit for routine analysis.