Category
Clobetasol propionate
CAS Number
Clobetasol Propionate- 25122-46-7;IMP-A- 5534-13-4 ; IMP-B- 1356190-17-4 ; IMP-D- 25120-99-4 ; IMP-E- NA
Molecular Formula
Clobetasol Propionate C25H32ClFO5;IMP-A- C25H33FO6; IMP-B- C22H26ClFO3; IMP-D-C25H34ClFO5; IMP-E- C25H33ClO4
Molecular Weight
Clobetasol Propionate 467.0 g/mol;IMP-A- 448.5 g/mol; IMP-B- 392.9 g/mol; IMP-D- 469.0 g/mol; IMP-E- 433.0 g/mol
Synonym

Clobetasol propionate - Clobederm; Clobesol; Clobetasol 17-Propionate; 21-Chloro-9-fluoro-11β-hydroxy-16β-methyl-3,20-dioxopregna-1,4-dien-17-yl propanoate; (8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-Chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate; 

Clobetasol propionate EP Impurity A - 9-Fluoro-11β,21-dihydroxy-16β-methyl-3,20-dioxopregna-1,4-dien-17-yl propanoate ; (11β,16β)-9-Fluoro-11,21-dihydroxy-16-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione; Betamethasone 17α-Propionate; (8S,9R,10S,11S,13S,14S,16S,17R)-9-Fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate;

Clobetasol propionate EP Impurity B - 21-chloro-9-fluoro-11β-hydroxy-16-methylpregna-1,4,16- triene-3,20-dione; (8S,9R,10S,11S,13S,14S)-17-(2-Chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15-decahydro-3H-cyclopenta[a]phenanthren-3-one;

Clobetasol propionate EP Impurity D -  21-Chloro-9-fluoro-11β-hydroxy-16β-methyl-3,20-dioxopregn-4-en-17-yl propanoate; (8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-Chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl Propionate;

Clobetasol propionate EP Impurity E - 21-Chloro-16β-methyl-3,20-dioxopregna-1,4-dien-17-yl propanoate; (8R,9S,10R,13S,14S,16S,17R)-17-(2-Chloroacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl Propionate;

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Purity:

Above - 95.0%

Technical Data:

We will provide complete documentation support for every Standard Material. All analytical reports such as ¹H NMR, ¹³C NMR, Mass, FT-IR, HPLC Purity/GC Purity/QNMR Purity, Water content by KF/ Loss on Drying/TGA (Thermo-gravimetric Analysis). Certificate of Analysis with potency report. Each Standard Material SER (Structure Elucidation Report) with NMR, Mass, IR spectral interpretation. This whole analytical document can be included in eCTD, ANDA, DMF submissions to regulatory agencies.

Clobetasol propionate CRS is used in system suitability and peak identification to confirm the drug’s identity and ensure accurate chromatographic analysis. It also helps detect impurities or degradation products in pharmaceutical formulations.