Category
Cilastatin
CAS Number
82009-34-5
Alternate CAS Number
81129-83-1 (Na salt)
Molecular Formula
C16H26N2O5S
Molecular Weight
358.5 g/mol
Synonym

(Z)-7-[[(2R)-2-amino-2-carboxyethyl]sulfanyl]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]hept-2-enoic acid ;

Keywords
Pharmaceuticals
Impurities
Intermediates
Metabolites.
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Purity:

Above - 95.0%

Technical Data:

We will provide complete documentation support for every Standard Material. All analytical reports such as ¹H NMR, ¹³C NMR, Mass, FT-IR, HPLC Purity/GC Purity/QNMR Purity, Water content by KF/ Loss on Drying/TGA (Thermo-gravimetric Analysis). Certificate of Analysis with potency report. Each Standard Material SER (Structure Elucidation Report) with NMR, Mass, IR spectral interpretation. This whole analytical document can be included in eCTD, ANDA, DMF submissions to regulatory agencies.

Cilastatin is a renal dehydropeptidase-I inhibitor used primarily in combination with imipenem to prevent its degradation in the kidneys. Although it has no antibacterial activity of its own, cilastatin enhances the stability, efficacy, and safety of imipenem and is widely analyzed in pharmaceutical quality control and system suitability testing.