Category
Chemical Primary Standard
CAS Number
4039-32-1
Molecular Formula
C6H18LiNSi2
Molecular Weight
167.33 g/mol
Synonym

1,1,1-Trimethyl-N-(trimethylsilyl)silanamine lithium Salt; [1,1,1-Trimethyl-N-(trimethylsilyl)silanaminato]lithium; Hexamethyldisilazane lithium salt; Lithium hexamethyldisilazane; Lithium hexamethyldisilazide; N,N-Bis(trimethylsilyl)amine lithium salt; N-Lithiohexamethyldisilazane;

Keywords
Miscellaneous compounds
Slide_1

Lithium bis(trimethylsilyl)amide (LiHMDS) is widely used as a strong, non-nucleophilic base in organic synthesis for deprotonation reactions and enolate formation. It is also used in the synthesis of pharmaceuticals and fine chemicals, particularly in alkylation, acylation, and condensation reactions.