Category
Chemical Primary Standard
CAS Number
80029-43-2
Molecular Formula
C6H7N3O2
Molecular Weight
153.14 g/mol
Synonym

1H-Benzotriazole, 1-hydroxy-, Monohydrate; 1H-Benzo[d][1,2,3]triazol-1-ol Hydrate; 1-Hydroxybenzotriazole Monohydrate; 1-Hydroxybenzotriazole Hydrate;

Keywords
Miscellaneous compounds
Slide_1

1H-Benzotriazole, 1-hydroxy-, Hydrate (commonly called hydroxybenzotriazole hydrate, HOBt·H₂O) is a reagent used in peptide synthesis to improve coupling efficiency. It is primarily applied in organic and pharmaceutical chemistry as a coupling additive that minimizes racemization and enhances the formation of amide bonds during peptide and protein synthesis.