Category
Cabazitaxel
CAS Number
Cabazitaxel - 183133-96-2 ; IMP-C- NA ;IMP-D- 3070439-24-3;IMP-E- 1714967-26-6; IMP-F- NA ; IMP-G- NA
Molecular Formula
Cabazitaxel C45H57NO14 ; IMP-C- C46H59NO14;IMP-D- C58H72N2O18 ;IMP-E- C58H72N2O18; IMP-F- C53H63NO15 ; IMP-G- C58H72N2O18
Molecular Weight
Cabazitaxel - 835.9 g/mol ; IMP-C- 850.0 g/mol ;IMP-D- 1085.2 g/mol ;IMP-E- 1085.2 g/mol ; IMP-F- 954.1 g/mol ; IMP-G- 1085.2 g/mol
Synonym

Cabazitaxel -  (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate 

Cabazitaxel EP Impurity C - (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-4,6,11-trimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate; 4-(Acetyloxy)-13α-[[(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl]oxy]-1,7β,10β-trimethoxy-9-oxo-4α,5β-5,20-epoxytax-11-en-2α-yl Benzoate

Cabazitaxel EP Impurity D - 4-(Acetyloxy)-7α,13α-bis[[(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl]oxy]-1-hydroxy-10β-methoxy-9-oxo-5β,20-epoxytax-11-en-2α-yl benzoate; (2aR,4R,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-12-(benzoyloxy)-11-hydroxy-6-methoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxete-4,9-diyl (2R,2'R,3S,3'S)-bis(3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoate);

Cabazitaxel EP Impurity E - (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-12-(benzoyloxy)-11-hydroxy-6-methoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxete-4,9-diyl (2R,2'R,3S,3'S)-bis(3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoate);

Cabazitaxel EP Impurity F - 5-((2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-12-(benzoyloxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-9-yl) 3-(tert-butyl) (2R,4S,5S)-2-(4-methoxyphenyl)-4-phenyloxazolidine-3,5-dicarboxylate

Cabazitaxel EP Impurity G - (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-Acetoxy-12-(benzoyloxy)-11-hydroxy-4-methoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxete-6,9-diyl (2R,2'R,3S,3'S)-bis(3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoate);

 

 

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Purity:

Above - 95.0%

Technical Data:

We will provide complete documentation support for every Standard Material. All analytical reports such as ¹H NMR, ¹³C NMR, Mass, FT-IR, HPLC Purity/GC Purity/QNMR Purity, Water content by KF/ Loss on Drying/TGA (Thermo-gravimetric Analysis). Certificate of Analysis with potency report. Each Standard Material SER (Structure Elucidation Report) with NMR, Mass, IR spectral interpretation. This whole analytical document can be included in eCTD, ANDA, DMF submissions to regulatory agencies.

Cabazitaxel for peak identification CRS is used as a reference standard in chromatographic analysis to accurately identify the Cabazitaxel peak. It helps confirm specificity and reliability of analytical methods during quality control testing.