Category
Amlodipine
CAS Number
2418591-36-1
Molecular Formula
C₂₀H₂₃ClN₂O₆
Molecular Weight
422.86 g/mol
Synonym

2-((2-Aminoethoxy)methyl)-4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methylpyridine 1-oxide ; Dehydro Amlodipine N-oxide; 3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1-oxidopyridin-1-ium-3,5-dicarboxylate

Keywords
Impurities
Metabolites.
Pharmaceutical Standards
Intermediates
Fine Chemicals
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Dehydro Amlodipine N-oxide is a known related substance/impurity of amlodipine, formed through oxidation of the nitrogen atom in the amlodipine molecule. It is monitored in pharmaceutical formulations to ensure drug purity, safety, and stability, as its presence above accepted limits can affect efficacy. Regulatory guidelines like ICH and pharmacopeias provide limits for such oxidative impurities during quality control.