Teriflunomide is an oral immunomodulatory drug used mainly for the treatment of relapsing forms of multiple sclerosis. It works by selectively inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase, thereby reducing de novo pyrimidine synthesis and limiting the proliferation of activated T and B lymphocytes involved in autoimmune inflammation. Teriflunomide is the active metabolite of leflunomide and was developed to provide a more targeted and convenient once-daily therapy for long-term management of multiple sclerosis.
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