Mitomycin is a powerful antitumor antibiotic that inhibits DNA synthesis by crosslinking DNA strands, leading to cancer cell death. It is effective against solid tumors like gastric, pancreatic, and bladder cancers, and is also used in ophthalmic procedures to reduce scarring. Discovered in 1956 from the soil bacterium Streptomyces caespitosus, mitomycin became a key chemotherapeutic agent, both alone and in combination, representing a major advancement in cancer treatment.
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