Methylergometrine, also known as methylergometrine maleate or methylergometrine tartrate, is a semisynthetic ergot alkaloid primarily used to prevent or treat postpartum hemorrhage by inducing strong and sustained uterine contractions. It acts directly on uterine smooth muscle and also has vasoconstrictive properties through its interaction with adrenergic and serotonergic receptors. Developed in the mid-20th century as part of efforts to improve maternal care and reduce childbirth-related complications, methylergometrine offered a more potent and predictable alternative to natural ergot derivatives. Over the decades, it has become a cornerstone in obstetric practice for controlling uterine bleeding after delivery, valued for its efficacy, rapid action, and role in reducing maternal mortality worldwide.
