Glucose is a form of sugar derived from the foods we consume and used by our bodies for energy. It is also known as dextrose when detected in food and glucose when discovered in the bloodstream. Glucose enters the body as monosaccharides, disaccharides, or polysaccharides. Excess glucose is stored in the body as glycogen, a glucose polymer used during fasting. When glucose enters the body, the sugar molecules move through the bloodstream to energy-requiring tissues. It proceeds through a sequence of metabolic events, releasing energy as adenosine triphosphate. Glucose is essential for the proper functioning of every organ. The liver, pancreas, adrenal gland, thyroid gland, anterior pituitary gland, and hormones like insulin, glucagon, cortisol, thyroxine, growth hormone, epinephrine, and adrenocorticotropic hormones play an important role in regulating glucose levels.
USES:
- Glucose is used to treat Hypoglycemia, high levels of potassium in the blood, and to provide calories to sick people when they are not able to eat food.
- It is used to create cellulose, a tough molecule that forms the cell walls of the plant cells.
- It is used to create starch in the plant cells as grains that are complex carbohydrates stored in plants.
- Glucose is used as a precursor for the synthesis of other substances.
- Glucose is the body's principal source of energy, with most cells producing energy from it. Glucose is required for normal brain function because it aids nerve cells and chemical messengers in the processing of information.
DOSAGE:
Glucose is available in intravenous solutions and oral liquids.
- Intravenous solutions are available in strengths of 2.5%, 5%, 10%, 20%, 30%, 50% and 70%. Oral liquid is available with a strength of 55%.
- If hypertonic 10% dextrose solutions are administered peripherally, use a large arm vein, possibly an alternate injection site daily.
- For the treatment of severe hypoglycemia, higher concentrations of dextrose injections should be administered through central veins only after appropriate dilution. For treating hypoglycaemia it is administered intravenously 10 – 25g.
ADVERSE EFFECTS:
- Edema
- Venous thrombosis
- Fever
- Diarrhea
- Hypermolar syndrome
- Injection site extravasation
- Cerebral haemorrhage
- Unconsciousness
- Mental confusion
- Injection site inflammation
- Increased blood sugar
OVERDOSE:
Taking excess doses of glucose can lead to toxic effects
- Kidney failure
- Eye problems
- Nerve damage
- Heart failures
PHARMACEUTICAL USES:
Glucose is the primary component for most cells to generate energy.
- It is used in treating hyperkalemia or high levels of potassium in the blood.
- Glucose is used to treat hypoglycemia by increasing the concentration of glucose in the blood. It is rapidly absorbed from the intestines into the bloodstream, alleviating the symptoms of low blood sugar.
- It is used to provide calories and carbohydrates to patients who are unable to take food orally.
- It is also used to treat people who are sick from drinking alcohol in large quantities.
DERIVATIVE PRODUCTS:
- Methyl beta-d-galactopyranoside
- Propylene glycol
- Glucosamine
- Methyl and ethyl alcohol glucosides
- N-acetylglucosamine
- Gluconate
- Sorbitol
- Mannopyranoside
- Methyl alpha-d-glucopyranose
- N-plmitoylucosamine