Fluocinolone acetonide is a synthetic corticosteroid with anti-inflammatory, anti-pruritic, and vasoconstrictive effects, commonly used to treat eczema, psoriasis, and dermatitis by modulating glucocorticoid receptors to reduce inflammation and immune response. It was developed in the 1960s–1970s to provide a more potent and longer-acting topical steroid with fewer systemic effects than earlier agents, and over time it has been formulated in creams, ointments, and intralesional preparations. While highly effective, its use requires monitoring due to potential local and systemic side effects, yet it remains a key drug in dermatological therapy.
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