Etofenamate is a non-steroidal anti-inflammatory drug (NSAID) belonging to the flufenamic acid derivative class. It is primarily used for its analgesic, anti-inflammatory, and antirheumatic properties. The drug is commonly applied in the management of musculoskeletal disorders such as arthritis, tendonitis, and sprains. Etofenamate works by inhibiting cyclooxygenase (COX) enzymes, reducing the synthesis of prostaglandins responsible for pain and inflammation. It is available in various formulations, including topical gels, creams, and lotions, allowing localized treatment. The drug provides rapid relief with minimal systemic side effects compared to oral NSAIDs. Etofenamate was first introduced in the late 20th century and has been widely adopted in clinical practice. Its safety and efficacy profile make it suitable for both short-term and long-term management of inflammatory conditions. The topical route enhances patient compliance due to ease of application and targeted effect. Etofenamate continues to be an important option in the therapeutic management of localized inflammatory and painful conditions.
