Eplerenone is a selective aldosterone receptor antagonist used primarily to treat conditions such as hypertension and heart failure, particularly after myocardial infarction. By blocking aldosterone, it helps reduce sodium retention, water retention, and cardiac remodeling, improving cardiovascular outcomes. Eplerenone was developed in the 1980s and introduced in the early 2000s as a safer alternative to spironolactone, with fewer hormonal side effects due to its higher selectivity for mineralocorticoid receptors. Since its introduction, it has become an important therapy in managing cardiovascular diseases, offering both efficacy and improved tolerability.
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